Multifunctional Surfaces for Improving Soft Tissue Integration

Metallic implants are widely used in diverse clinical applications to aid recovery from lesions or replace native hard tissues. However, the lack of integration metallic surfaces with soft tissue interfaces causes occurrence biomaterial-associated infections, which can trigger a complicated inflammatory response and, ultimately, implant failure. Here, multifunctional surface showing nanoscale anisotropy, based on controlled deposition cellulose nanocrystals (CNC), and biological activity derived platelet lysate (PL) biomolecules sequestered presented CNC surface, is proposed. The anisotropic radial nanopatterns produced polished titanium by spin-coating at high speed. Furthermore, chemistry allows further sequester form coating bioactive molecules PL. anisotropy provided guides fibroblasts growth alignment up 14 days culture. Moreover, PL-derived polarize macrophages toward M2-like anti-inflammatory phenotype. These results suggest that developed promote same time, prevent bacterial invasion, inflammation, failure biomedical implants.